What titration means
To titrate a medication is to adjust its dose in deliberate steps rather than starting at the full amount. With GLP-1 medications, titration almost always means increasing the dose over time — beginning at a low starting dose and stepping up on a set schedule until you reach the maintenance dose that balances results against tolerability.
Why every GLP-1 is titrated
These drugs slow stomach emptying and act on the gut, so introducing a full dose immediately tends to cause strong nausea, vomiting, and other GI effects. Titration sidesteps most of that: each small increase gives your body weeks to adapt before the next step up. Wegovy, Ozempic, Mounjaro, and Zepbound all ship with a built-in escalation schedule for exactly this reason.
Titration is about the timeline and side effects, not the specific numbers. For the step-by-step schedule for a given drug, use the dose calculator or the dosage charts — this page just explains what the word means and why the slow ramp exists.